NASA Spaceline Current Awareness List #945 16 April 2021 (Space Life Science Research Results)
Posted: Friday, April 16, 2021
Papers deriving from NASA support:
Austermann K, Baecker N, Zwart SR, Fimmers R, Frippiat JP, Stehle P, Smith SM, Heer M.
Antioxidant supplementation does not affect bone turnover markers during 60 days of 6° head-down tilt bed rest: Results from an exploratory randomized controlled trial.
J Nutr. 2021 Apr 8;nxab036. Online ahead of print.
PI: S.M. Smith for the US portion.
Note: Head-down tilt bed rest study.
Journal Impact Factor: 4.281
Funding: “Funded by the German Aerospace Center (DLR) Space Program with allocation of funds from the Federal Ministry of Economy and Technology under the support code 50WB1535, and in part by the European Space Agency, the Centre National d’Etudes Spatiales and the Human Health Countermeasures Element of the National Aeronautics and Space Administration Human Research Program.”
Clark TK, Merfeld DM.
Statistical approaches to identifying lapses in psychometric response data.
Psychon Bull Rev. 2021 Apr 6. Review. Online ahead of print.
PI: T.K. Clark
Note: From the article: “Utilizing signal-detection theory, psychometric curve fits are widely used to quantify an observer’s performance. Subject lapses caused by loss of attention can cause fit parameters to fall far from actual values. Accurate psychometric curve fits are critical to ensure accurate and appropriate experimental conclusions. We test a novel lapse-identification algorithm that simulations show reduces the impact of lapses across a wide range of underlying lapse rates. Further simulations show the algorithm to be effective across a broad range of experimental conditions.”
Journal Impact Factor: 3.910
Funding: “This work was supported by the National Space Biomedical Research Institute (NSBRI) through NASA Grant NCC9-58 (T.K. Clark) and via National Institute of Deafness and Other Communications Disorders Grants R01DC04158 and R01DC014924 (D.M. Merfeld).”
Tesei D, Chiang AJ, Kalkum M, Stajich JE, Mohan GBM, Sterflinger K, Venkateswaran K.
Effects of simulated microgravity on the proteome and secretome of the polyextremotolerant black fungus Knufia chersonesos.
Front Genet. 2021 Mar 18;12:638708.
PI: K. Venkateswaran
Note: A Rotary Cell Culture System with high-aspect-ratio vessels was used. This article may be obtained online without charge.
Journal Impact Factor: 3.258
Funding: “This research was funded by the Austrian Science Fund (FWF, Der Wissenschaftsfonds) project T872 Firnberg-Programm awarded to DT. A 2012 NASA Space Biology grant no. 19-12829-26 under Task Order NNN13D111T was awarded to KV which also supported GBMM. The Mass Spectrometry and Proteomics Core Facility at the City of Hope was supported in part by the National Cancer Institute of the National Institutes of Health under award no. P30CA033572. AC and MK were supported by Jet Propulsion Laboratory (JPL) subcontract no. 1611422.”
Other papers of interest:
Uda Y, Spatz JM, Hussein A, Garcia JH, Lai F, Dedic C, Fulzele K, Dougherty S, Eberle M, Adamson C, Misener L, Gerstenfeld L, Divieti Pajevic P.
Global transcriptomic analysis of a murine osteocytic cell line subjected to spaceflight.
FASEB J. 2021 May;35(5):e21578.
Note: ISS results.
Glebova ТМ, Koloteva MI, Orlov OI, Ovchinin AN, Vasin AV, Konovalova IV, Salnikov AV.
[G-tolerance of the ISS crew during the ballistic landing after off-nominal launch of space vehicle Soyuz].
Aviakosm Ekolog Med. 2021;55(1):33-7. Russian.
Note: ISS results.
Larina IM, Buravkova LB, Grigoriev AI.
[Oxygen-dependent adaptation processes in the human organism in usual living conditions and during space flight].
Aviakosm Ekolog Med. 2021;55(1):5-19. Russian.
Note: The particular spaceflights are not identified in the available English abstract. From the abstract: “The review examines various parties of oxygen-dependent human adaptation to microgravity belonging to different levels of the integral system organization. Particular emphasis has been placed on the cellular sensing systems of immediate and chronic reactions to altered O2 delivery. The authors expound the key oxygen sensors and heterogeneity of the sensing mechanisms. They also concern themselves with the role of O2 active forms and O2-sensing elements developing in the spaceflight environment.”
Proshchina A, Gulimova V, Kharlamova A, Krivova Y, Besova N, Berdiev R, Saveliev S.
Reproduction and the early development of vertebrates in space: Problems, results, opportunities.
Life. 2021;11(2):109. Review.
Wang H, Dong J, Li G, Tan Y, Zhao H, Zhang L, Wang Y, Hu Z, Cao X, Shi F, Zhang S.
The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation.
Biochem Biophys Res Commun. 2021 Apr 2;555:175-81. Online ahead of print.
Note: A 2D clinostat was used in this study. This article may be obtained online without charge.
Man’ko ОМ, Smoleevsky АЕ, Tomilovskaya ЕS.
[Change in eye hydrodynamics as a pathogenesis factor of the space-flight associated neuro-ocular syndrome (SANS)].
Aviakosm Ekolog Med. 2021;55(1):38-45. Review. Russian.
Note: Dry immersion was used. From the abstract: “This work extended the previous studies of ocular hydrodynamics during 5-day simulation of the microgravity body effects by dry immersion. We present the results of intraocular hydrobalance analysis after 21-d DI with participation of 8 male subjects at the age of 24 to 35 years.”
[Modeling radiation loading of radiation monitor RADOM onboard space vehicle Chandrayaan-1 during its flight within Earth’s magnetosphere].
Aviakosm Ekolog Med. 2021;55(1):76-81. Russian.
Note: Results from the Indian spacecraft Chandrayaan-1. From the abstract: “The paper describes our efforts to model the radiation environment of RADOM onboard Chandrayaan-1 launched to the Moon on 22.10.2008, including the vehicle design in order to assess its shielding function.”
Oshurkova VI, Deshevaya ЕА, Suzina NE, Shubralova NE, Shcherbakova VA.
[Methanogenic archaea in the space environment].
Aviakosm Ekolog Med. 2021;55(1):63-9. Russian.
Note: From the abstract: “Next phase of experiment TEST is aimed to evaluate microbial viability after a prolonged external exposure on the International space station (ISS). Methanogenic archaea isolated from various habitats have been tested in ground facilities for the ability to survive exposure to such open space factors as UV and vacuum. Methanosarcina mazei S-6T (VKM B-1636T) was found to be the most viable and, therefore, suitable for the experiment.”
Ilyin VK, Afonin BV, Komissarova DV, Shef KA, Agureev AN, Usanova NA, Valuev VA, Dzekh SA.
[Investigation of the effect of changes in gut microflora and preventive taking of probiotics on the functional state of the stomach during isolation study SIRIUS-18/19].
Aviakosm Ekolog Med. 2021;55(1):70-5. Russian.
Note: Sirius 18/19 isolation and confinement analog mission results.
Kuzichkin DS, Markin АА, Zhuravleva ОА, Krivitsina ZА, Vostrikova LV, Zabolotskaya IV, Loguinov VI.
[Study of the plasma component of the blood aggregation regulatory system in subjects in the experiment with 120-day isolation inside pressurized module SIRIUS-19].
Aviakosm Ekolog Med. 2021;55(1):59-62. Russian.
Note: SIRIUS-19 isolation and confinement analog mission results.
Waldvogel J, Ritzmann R, Freyler K, Helm M, Monti E, Albracht K, Stäudle B, Gollhofer A, Narici M.
The anticipation of gravity in human ballistic movement.
Front Physiol. 2021 Mar 17;12:614060.
Note: From the abstract: “This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g.” This article may be obtained online without charge.
Nday CM, Frantzidis CA, Plomariti C, Gilou SC, Ntakakis G, Jackson G, Chatziioannidis L, Bamidis PD, Kourtidou-Papadeli C.
Human blood adenosine biomarkers and non-rapid eye movement sleep stage 3 (NREM3) cortical functional connectivity associations during a 30-day head-down-tilt bed rest analogue: Potential effectiveness of a reactive sledge jump as a countermeasure.
J Sleep Res. 2021 Apr 7;e13323. Online ahead of print.
Note: Head-down tilt bed rest study.
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